[{
  "type": "article-journal",
  "title": "EXPLORING OF THE PROTECTIVE EFFECTS OF CHINAR (PLATANUS ORIENTALIS L.) LEAF ON TESTES DAMAGE INDUCED BY ETHANOL IN RAT MODEL",
  "author": [
    {
      "family": "YAMAN",
      "given": ""
    },
    {
      "family": "DOGAN",
      "given": ""
    },
    {
      "family": "KELES",
      "given": ""
    },
    {
      "family": "Dönmez",
      "given": ""
    },
    {
      "family": "BATTAL",
      "given": ""
    },
    {
      "family": "Anuk",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2024]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "34",
  "issue": "2",
  "page": "374-386",
  "DOI": "https://doi.org/10.36899/JAPS.2024.2.0724",
  "abstract": "<p>The aim of this study was to investigate the protective effects of an infusion obtained from dried Chinar (<em>Platanus orientalis</em> L.; PO) leaves against ethanol-induced damage in rat testes. 30 male Wistar rats were divided into five groups: Control, Ethanol 20%, Ethanol 20% + Silymarin (10 mg/kg/day), Ethanol 20% + PO-20 mg/mL infusion and Ethanol 20% + PO-60 mg/mL infusion. Histopathologically, ethanol-induced damage, including the depletion of germ cells and loss of spermatozoa, was significantly improved in the Ethanol + PO-60 group. Immunohistochemically, an increase in the expression of endothelial nitric oxide synthase (eNOS) and caspase-3 was observed in ethanol group. Treatment with the PO extract markedly reduced the ethanol-induced expression of eNOS and caspase-3 in the Ethanol + PO-60 group. According to biochemical results, both of the PO infusion treatments caused decrease in malondialdehyde levels compare to ethanol group. &nbsp;On the other hand, glutathione contents in treatment groups were significantly higher than ethanol group. Fluctuations in antioxidant defense enzyme levels were determined. PO leaf might have a protective role against ethanol-induced testicular damage in rats by inducing apoptosis via the upregulation of eNOS expression and preventing lipid peroxidation.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2023-JAPS-1022"
}]