[{
  "type": "article-journal",
  "title": "GENOME-WIDE ANALYSIS REVEALS THE MOLECULAR BASIS OF GENETIC VARIATION OF IMPORTANT ECONOMIC TRAITS IN CASHMERE GOATS ON QINGHAI-TIBET PLATEAU",
  "author": [
    {
      "family": "tian",
      "given": ""
    },
    {
      "family": "zhao",
      "given": ""
    },
    {
      "family": "Zhou",
      "given": ""
    },
    {
      "family": "Han",
      "given": ""
    },
    {
      "family": "Li",
      "given": ""
    },
    {
      "family": "Tian",
      "given": ""
    },
    {
      "family": "Qi",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2023]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "33",
  "issue": "6",
  "page": "1474-1489",
  "DOI": "https://doi.org/10.36899/JAPS.2023.6.0687",
  "abstract": "<p><span lang=\"EN-US\">Qaidam Cashmere goat is one of the few animals that can survive in the harsh environment of the Qinghai-Tibet Plateau and the adjacent alpine areas. It has a strong adaptability, thus shaping the genetic diversity of goat phenotype, morphology, physiology and other aspects. However, the molecular basis behind these genetic mechanisms remains unclear. Here, we conducted genome-wide studies of genetic variation in two different morphologies and geographical coordinates in indigenous Chinese goats to identify selective signaling in genomic regions. In the present study,&nbsp;</span><span lang=\"EN-US\">w</span><span lang=\"EN-US\">e resequenced 10 high-altitude Chinese indigenous goat breeds and compared them with low-altitude goats.</span><span lang=\"EN-US\">By combining &theta;&pi; and Fst values, we identified 1277 overlapping selection regions that may contribute to the wool fiber traits, reproductive performance, and high-altitude adaptation of goats.</span><span lang=\"EN-US\">Candidate genes enriched in selected regions are associated with the phenotypes in cashmere fiber traits (IGFBP3, TNF, ROCK1, WNT10B, KITLG), reproduction traits (CAMK2D, IL-18, ESR1, ANAPC13), body size (POMC), hypoxic adaptation (TH, ACER1, GNB1, HIF1A) and disease (IL-10).&nbsp;</span><span lang=\"EN-US\">This study provided valuable genetic information for the basis of biological characteristics and genetic improvement of br</span><span lang=\"EN-US\">eeds.</span></p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2022-JAPS-693"
}]