[{
  "type": "article-journal",
  "title": "EFFECT OF G.13700A>G AND G.25783C>T IN PIT-1 GENE ON GROWTH TRAITS OF DUROC, LANDRACE, YORKSHIRE PIG",
  "author": [
    {
      "family": "DONG",
      "given": ""
    },
    {
      "family": "LIU",
      "given": ""
    },
    {
      "family": "WANG",
      "given": ""
    },
    {
      "family": "CHEN",
      "given": ""
    },
    {
      "family": "BAI",
      "given": ""
    },
    {
      "family": "LAN",
      "given": ""
    },
    {
      "family": "WANG",
      "given": ""
    },
    {
      "family": "LI",
      "given": ""
    },
    {
      "family": "YAN",
      "given": ""
    },
    {
      "family": "LU",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2023]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "33",
  "issue": "6",
  "page": "1286-1291",
  "DOI": "https://doi.org/10.36899/JAPS.2023.6.0668",
  "abstract": "<p>Pituitary specific transcription factor-1 (<em>Pit</em>-1) gene is responsible for pituitary development and growth hormone expression, which is considered a pivotal candidate gene for growth in pig. This study aims to detect novel single nucleotide polymorphisms (SNPs) in porcine<em>&nbsp;Pit</em>-1 gene, investigate its effect on growth traits in the Duroc, Landrace and Yorkshire pigs. Two novel polymorphisms were detected, one located in the intron 2 (g. 13700 A&gt;G) and another located in exon 4 (g.25783 C&gt;T) which caused an amino acid change from threonine to methionine (Thr36Met). At g.13700 A&gt;G site, the frequency of A allele was higher than G allele in Duroc, Landrace and Yorkshire. At the g.25783 C&gt;T site, it was remarkable differences in allelic frequencies and genotypic frequencies among the three pig breeds. This study demonstrated the significant genotype effect of&nbsp;<em>Pit-1</em>&nbsp;on body weights at 70 d, age when reached 30kg, 50kg, 100kg and average daily gain from 30kg to 100kg. According to our results, the novel&nbsp;<em>Pit</em>-1 polymorphisms may be useful in pig selection as molecular markers and required in future studies.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2022-JAPS-146"
}]