[{
  "type": "article-journal",
  "title": "ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN NOD1 AND NLRP9 GENES WITH FECAL EGG COUNT TRAIT OF CHINESE AND BANGLADESHI GOAT BREEDS BEING NATURALLY INFECTED BY HAEMONCHUS CONTORTUS",
  "author": [
    {
      "family": "Omar",
      "given": ""
    },
    {
      "family": "Yin",
      "given": ""
    },
    {
      "family": "Inayat",
      "given": ""
    },
    {
      "family": "Alam",
      "given": ""
    },
    {
      "family": "Zhenyang",
      "given": ""
    },
    {
      "family": "Worku",
      "given": ""
    },
    {
      "family": "Thi",
      "given": ""
    },
    {
      "family": "Faruque",
      "given": ""
    },
    {
      "family": "Periasamy",
      "given": ""
    },
    {
      "family": "Samsuddin",
      "given": ""
    },
    {
      "family": "Zhao",
      "given": ""
    },
    {
      "family": "Du",
      "given": ""
    },
    {
      "family": "Liu",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2019]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "29",
  "issue": "2",
  "page": "370-378",
  "DOI": "NA",
  "abstract": "<p>The study was conducted to identify relationships between single nucleotide polymorphisms (SNPs) in the&nbsp;<em>NOD1</em>&nbsp;and&nbsp;<em>NLRP9&nbsp;</em>genes and resistance to&nbsp;<em>H. contortus&nbsp;</em>infestation in goats in China and Bangladesh. A total of 507 unrelated goats from 6 different populations were sampled. Fecal egg count (FEC) was determined and genomic DNA was extracted from those goats.&nbsp;<a id=\"OLE_LINK98\" name=\"OLE_LINK98\"></a><a id=\"OLE_LINK97\" name=\"OLE_LINK97\">Touchdown PCR assays were used</a>&nbsp;to genotype each of the target SNP. An association study was carried out using a generalized linear model and R software after transforming the FEC as log10 (FEC + 25). All breeds of goat in Bangladesh had lower mean FEC than any of the Chinese breeds.<a id=\"OLE_LINK49\" name=\"OLE_LINK49\"></a><a id=\"OLE_LINK48\" name=\"OLE_LINK48\">&nbsp;Two</a><a id=\"OLE_LINK40\" name=\"OLE_LINK40\"></a><a id=\"OLE_LINK41\" name=\"OLE_LINK41\">&nbsp;single nucleotide polymorphisms (SNPs)</a>&nbsp;viz.&nbsp;<em>NOD1</em>_146_A&gt;G (p&lt;0.001) and&nbsp;<em>NLRP9</em>_43_A&gt;G (p&lt;0.003) were significantly associated with FEC trait after&nbsp;<em>H</em><em>.</em><em>&nbsp;contortus&nbsp;</em>infection.&nbsp;<a id=\"OLE_LINK80\" name=\"OLE_LINK80\"></a><a id=\"OLE_LINK81\" name=\"OLE_LINK81\"></a>Goats with the GG genotype for&nbsp;<em>NOD1</em>_146_A&gt;G (904.43 &plusmn; 140.65epg) and the AA genotype for&nbsp;<em>NLRP9</em>_43_A&gt;G (1129.57 &plusmn; 196.5 epg) had higher FEC than goats with the AA genotype (396.68 &plusmn; 67.22 epg) or the GG genotype (399.12 &plusmn; 106.4 epg) at the respective loci.&nbsp;<em>NOD1&nbsp;</em>and&nbsp;<em>NLRP9</em>&nbsp;genes were significantly associated with FEC and might be related to resistance to&nbsp;<em>H. contortus</em>&nbsp;infection in goats.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2019-JAPS-204"
}]