[{
  "type": "article-journal",
  "title": "RECOMBINANT LENTIVIRUS VECTOR TARGETING BOVINE LXRΑ MRNA AND ITS SILENCING EFFECTS ON BOVINE MUSCLE SATELLITE CELLS",
  "author": [
    {
      "family": "Liu",
      "given": ""
    },
    {
      "family": "Lib",
      "given": ""
    },
    {
      "family": "Zhao",
      "given": ""
    },
    {
      "family": "Zhao",
      "given": ""
    },
    {
      "family": "Li",
      "given": ""
    },
    {
      "family": "Liu",
      "given": ""
    },
    {
      "family": "Yang",
      "given": ""
    },
    {
      "family": "Zan",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2017]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "27",
  "issue": "6",
  "page": "1847-1851",
  "DOI": "NA",
  "abstract": "<p>The liver X receptor &alpha; (<em>LXR&alpha;)&nbsp;</em>is a member of the nuclear hormone receptor superfamily which could regulate the transcription of the genes involved in cholesterol transportation. In this study, Lentiviral vector containing<em>&nbsp;LXR&alpha;&nbsp;</em>shRNAs were constructed and transferred in bovine muscle satellite cells. The results indicated that&nbsp;<em>LXR&alpha;&nbsp;</em>down regulated&nbsp;<em>PPAR&alpha;</em>,&nbsp;<em>PPAR&gamma;</em>,&nbsp;<em>ABCA1</em>,&nbsp;<em>LPL</em>,&nbsp;<em>ApoE&nbsp;</em>genes after 48 h post-pLenti-03 viruses' infection. The silencing effects of bovine&nbsp;<em>LXR&alpha;&nbsp;</em>gene on related were significant. This work identifies bovine<em>&nbsp;LXR&alpha;&nbsp;</em>role in cholesterol metabolism.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2017-JAPS-234"
}]