[{
  "type": "article-journal",
  "title": "HISTOPATHOLOGICAL EFFECTS OF BISPHENOL-A ON LIVER, KIDNEYS AND GILLS OF INDIAN MAJOR CARP, CATLA CATLA (HAMILTON, 1822)",
  "author": [
    {
      "family": "Faheem",
      "given": ""
    },
    {
      "family": "Jahan",
      "given": ""
    },
    {
      "family": "Lone",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2016]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "26",
  "issue": "2",
  "page": "514-522",
  "DOI": "NA",
  "abstract": "<p>Bisphenol-A (BPA) is a xenoestrogen that mimics the action of natural estrogen, estradiol-17&beta;, and can disrupt the endocrine system. Present study was designed to investigate histopathological effects of BPA on some vital organs of major carp,&nbsp;<em>Catla catla</em>. Fish were exposed to various sub-lethal concentrations (1 to 4 ppm) of BPA in a semi-static system for 15 days.&nbsp; After the stipulated time, liver, kidneys and gills were dissected out and fixed immediately in 10 % buffered formalin. After embedding in paraffin wax, 5 micron thick sections were cut and stained with H &amp; E and PAS stains.&nbsp; In liver, BPA caused central vein congestion, inflammation, edema, degeneration and necrosis of hepatocytes. Kidney anomalies included obliteration of bowmen&rsquo;s space, shrinkage and degeneration of tubules and glomerulus. Gills responded to BPA stress by hyperplasia of mucous cells, clubbing and degeneration of secondary-lamellae. The present study revealed that BPA causes degenerative changes in various vital organs of&nbsp;<em>C. catla&nbsp;</em>and severity of histological changes were dose-related.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2016-JAPS-69"
}]