[{
  "type": "article-journal",
  "title": "URINARY BLADDER RELAXANT EFFECT OF ARTEMISIA VULGARIS AND ASPALATHUS LINEARIS",
  "author": [
    {
      "family": "Khan",
      "given": ""
    },
    {
      "family": "Gilani",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2015]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "25",
  "issue": "6",
  "page": "1779-1781",
  "DOI": "NA",
  "abstract": "<p>In isolated rabbit urinary bladder preparations,&nbsp;<em>Artemisia vulgaris&nbsp;</em>(Av.Cr) crude extract inhibited the contractions produced by carbachol (CCh, 1 &micro;M) and high K+ (80 mM) in a &nbsp;concentration-dependent (0.03-10 mg/mL) manners. The crude extract of&nbsp;<em>Aspalathus linaeris&nbsp;</em>(Al. Cr) relaxed the contractions produced by low K+ (25 mM) at concentration range of 0.3-1.0 mg/mL, having moderate inhibitory effect on contractions produced by K+ (80 mM). Contractions induced by low K+ were partially antagonized by glibenclamide (3 &micro;M). These results indicate that urinary bladder relaxation produced by&nbsp;<em>Artemisia vulgaris</em>&nbsp;extract is mediated via dual, anticholinergic and Ca++ antagonist mechanisms, while that of&nbsp;<em>Aspalathus linaris&nbsp;</em>via dominant KATP channel opening and weak Ca++ channel blockade pathways. Thus the present study reveals the&nbsp;<em>Artemisia vulgaris&nbsp;</em>and<em>&nbsp;Aspslathus linaeris</em> medicinal usefulness in hyperactive bladder disorders</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2015-JAPS-239"
}]