[{
  "type": "article-journal",
  "title": "ANTI-HYPERCHOLESTEROLEMIC AND ANTI-ATHEROGENIC ACTIVITY OF Terminalia chebula FRUIT IN NORMAL AND CHOLESTEROL FED RABBITS",
  "author": [
    {
      "family": "Anjum",
      "given": ""
    },
    {
      "family": "Sayyed",
      "given": ""
    },
    {
      "family": "Ullah",
      "given": ""
    },
    {
      "family": "Mughal",
      "given": ""
    },
    {
      "family": "Yaqub",
      "given": ""
    },
    {
      "family": "Rashid",
      "given": ""
    },
    {
      "family": "Yousaf",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2014]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "24",
  "issue": "6",
  "page": "1618-1622",
  "DOI": "NA",
  "abstract": "<p>Over the centuries plants have been effectively used as a potent source of traditional medicine. Present experiment was aimed to evaluate the hypocholesterolemic and anti-atherogenic effect of feeding&nbsp;<em>Terminalia chebula&nbsp;</em>powder (TCP)in rabbits. A total of (n=20) rabbits were assigned to four treatment groups with n=5 animals in each group. Experimental treatments received Normal Saline (NS);&nbsp;<em>T. chebula</em>&nbsp;powder (TCP), high fat diet (HFD) and high fat diet plus&nbsp;<em>T. chebula</em>&nbsp;powder (HFDTCP). Blood samples were taken on a weekly basis to diagnose the effects of test drug on serum Total Cholesterol (TC), LDL, HDL, Triglycerides (TG) and Atherogenic Index. All the parameters were measured in mg/dl except the atherogenic index measured in units. In HFD rabbits TC (362.59&plusmn;6.00), LDL (262.59&plusmn;6.12) triglycerides (258.7&plusmn;2.90) and atherogenic index (13.50&plusmn;1.20) was higher (p &lt;0.05), while HDL (25.73&plusmn;1.09) was significantly reduced to an alarming level at the end of eight weeks. When HFD rabbits were treated with TCP for eight weeks, TC (132.60&plusmn;4.93), LDL (89.13&plusmn;2.75), Triglycerides (125.86&plusmn;9.06) and atherogenic index (1.54&plusmn;0.03) reduced significantly and increased (p &lt;0.05) the HDL (52.10&plusmn;1.50). It was therefore concluded that that&nbsp;<em>T. chebula</em> powder can safely be used to reduce bad cholesterol (LDL) and to enhance good cholesterol (HDL).&nbsp;</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-231"
}]