[{
  "type": "article-journal",
  "title": "PHARMACOKINETIC STUDY OF ENROFLOXACIN IN TIANFU GEESE",
  "author": [
    {
      "family": "Shi",
      "given": ""
    },
    {
      "family": "Tang",
      "given": ""
    },
    {
      "family": "Xie",
      "given": ""
    },
    {
      "family": "Anees",
      "given": ""
    },
    {
      "family": "Yang",
      "given": ""
    },
    {
      "family": "Zhang",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2014]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "24",
  "issue": "1",
  "page": "113-119",
  "DOI": "NA",
  "abstract": "<p>The pharmacokinetic behavior of enrofloxacin (EF) was investigated in geese after oral (<em>p.o.</em>) and intravenous (<em>i.v.</em>) administrations of a single dose of 20 mg/kg body weight. Plasma concentrations of EF and its active metabolite, ciprofloxacin, were determined by high performance liquid chromatography fluorescence method. Plasma concentrations versus time were analyzed by non-compartmental method. The elimination half-life and area under drug concentration-time curve from zero to infinity of EF after&nbsp;<em>i.v.</em>&nbsp;administration were 3.32 &plusmn; 0.43 h and 45.73 &plusmn; 5.74 mg/L&middot;h, respectively. After&nbsp;<em>p.o.</em>&nbsp;administration, EF was absorbed fast and the maximum plasma concentration of 3.86 &plusmn; 0.36 mg/L reached at 2.14 &plusmn; 1.10 h. The concentration-time profile of EF showed a double peak-shaped curve, indicating the possibility of enterohepatic recirculation of EF in geese. The bioavailability for EF after&nbsp;<em>p.o.</em>&nbsp;administration was 78.09 &plusmn; 25.76%. Seldom ciprofloxacin was detected in the plasma both after&nbsp;<em>i.v.</em>&nbsp;and&nbsp;<em>p.o.</em>&nbsp;administrations, indicating low transformation rate from EF to ciprofloxacin in geese. Taking into account the efficacy indices obtained, a single&nbsp;<em>p.o.</em> dose of 20 mg/kg of EF would be adequate for treating infections caused by highly susceptible bacteria in geese.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-17"
}]