[{
  "type": "article-journal",
  "title": "COMPARATIVE FUNCTION-STRUCTURAL ANALYSIS OF ANTIPLATELET AND ANTIRADICAL ACTIVITIES OF FLAVONOID PHYTOCHEMICALS",
  "author": [
    {
      "family": "Guo",
      "given": ""
    },
    {
      "family": "Liu",
      "given": ""
    },
    {
      "family": "Guo",
      "given": ""
    },
    {
      "family": "Yin",
      "given": ""
    },
    {
      "family": "Lin",
      "given": ""
    },
    {
      "family": "Chen…",
      "given": ""
    },
    {
      "family": "Sun",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2014]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "24",
  "issue": "3",
  "page": "926-935",
  "DOI": "NA",
  "abstract": "<p>The antiplatelet and antiradical activities of 8 dietary flavonoid phytochemicals were investigated and compared. Quercetin, rutin, isoquercitrin, hesperetin, naringenin, hesperidin, naringin and icariin inhibited ADP-induced rat platelet aggregation by 68.33&plusmn;2.43%, 55.34&plusmn;2.09%, 52.27&plusmn; 4.65%, 50.80&plusmn;7.03%, 33.07&plusmn;2.09%, 31.28&plusmn;4.65%, 22.91&plusmn;1.68% and 20.94&plusmn;3.20%, respectively. Only quercetin, rutin and isoquercitrin showed clear scavenging HO&middot; radical activity. Function-structure analysis indicated 1) flavonoids with more free phenolic hydroxyl groups showed relative higher antiplatelet and antiradical activities; 2) substitution of 7-OH of A ring affected antiplatelet capacities of flavanones apparently; 3) free 3-OH of C ring was important for both the antiplatelet and antiradical activities of flavonol (quercetin) and flavones (rutin, isoquercitrin); 4) C ring C2-C3 double bond and B ring 3&rsquo;-4&rsquo;orthodihydroxy might be important for its antiradical function. This study provides certain clues for evaluating a favorable dietary flavonoid drugs from our foods in prevention and treatment of related diseases associated with platelet aggregation and hyroxyl radical oxidation.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-130"
}]