EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF SALSOLA IMBRICATA FORSSK IN RATS
K. H. Janbaz1, N. Aslam1*, I. Imran1 and Q. Jabeen2
1Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
2Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, the Islamia University of Bahawalpur, Pakistan
*Author for correspondence, email: naveedbwppk@yahoo.com
ABSTRACT
Salsola imbricata has folkloric repute in the treatment of painful and inflammatory conditions. Therefore, present study was undertaken to assess the anti-inflammatory, analgesic and antipyretic activities of aqueous-ethanol crude extract of S. imbricata (Si.Cr) using models of carrageenan-induced paw edema, 4% NaCl-mediated abdominal writhing, formalin-induced paw licking and brewer’s yeast-mediated pyrexia in rats. The Si.Cr (100, 300 and 500 mg/kg, p.o.) significantly (p<0.001) inhibited carrageenan-induced paw edema in rats as compared to the saline treated control group. It inhibited writhes induced by intraperitoneal injection of 4% NaCl (p<0.001) as compared to the control group. In the first phase of formalin-induced paw licking test, Si.Cr (100 and 300 mg/kg) did not cause significant inhibition of nociception in rats, but at the dose of 500 mg/kg, it produced significant (p<0.05) reduction in time of licking paw by rats. Oral administration of Si.Cr (100, 300 and 500 mg/kg) reduced time of licking paw during the second phase of the formalin test. In addition, Si.Cr exhibited significant (p<0.001) antipyretic activity in brewer’s yeast-induced pyrexia in rats. This study, showing the presence of anti-inflammatory, analgesic and antipyretic activities in Si.Cr, supports uses of the plant in folk medicine.
Key words: Chenopodiaceae; carrageenan; formalin test; NaCl writhing test; yeast induced pyrexia. |