The simultaneous emergence of rice and weed seedlings under alternate wetting and drying field conditions favors high weed infestation in dry-seeded rice (DSR) systems. Due to high weed pressure in DSR, a single weed management approach often provides sub-optimal weed control. Therefore, weed management in DSR systems demands an integrated approach. Field experiments for weed management in dry-seeded rice were conducted at   Rice Research Institute, Kala Shah Kaku, Lahore, during 2010 and 2011. Weed control treatments i.e. bispyribac sodium, ethoxysulfuron, bispyribac sodium + hand weeding, ethoxysulfuron + hand weeding, single hand weeding, and double hand weeding were compared with the weedy check in a randomized complete block design. Results revealed that maximum weeds control (97.2%) was achieved in the double hand weeded plots and in the plots treated with bispyribac sodium + hand weeding (94.5%) during the first year. However, during the second-year maximum weed control (98.3%) was obtained in bispyribac sodium + hand weeded plots, which was at par with double hand weeding (93.5%) and ethoxysulfuron + hand weeding (93.0%). Bispyribac sodium + hand weeded plots produced a maximum number of tillers m-2 (338 and 297), the longest panicles (27 and 28.2 cm) with the maximum number of grains/panicle (116.3 and 121.8) during both years. The highest paddy yield (3.2-4.0 t ha-1) was also obtained from the plots where bispyribac sodium + hand weeding was performed, whereas, lowest paddy yield (0.9-1.1 t ha-1) was achieved in the nontreated plots. Results from the study concluded that integration of hand weeding with a post-emergence application of bispyribac sodium is the best weed management option in DSR for controlling weeds as well as higher paddy grain yield.