Contagious caprine pleuropneumonia (CCPP) is an important disease of small ruminants. An investigation on the prevalence of contagious caprine pleuropneumonia was carried out in randomly selected goats of Hyderabad and Tando Allahyar districts. The data regarding risk factors, such as; age, sex and breed associated to CCPP infections were obtained. A total of 200 blood samples were collected from CCPP suspected goats from studied area. The samples were screened using competitive Enzyme Linked Immuno-Sorbent Assay (C-ELISA) and Capri-Latex Agglutination Test (LAT). An overall prevalence of 24% and 20% was recorded among goats using Capri-LAT, while 20% and 17% of CCPP infections by C-ELISA in goat population of districts Hyderabad and Tando Allahyar, respectively. The non-significant difference (P>0.05) was found for both districts. Whereas, significant difference (P≤0.05) was observed for age and breed wise in both districts, breed wise prevalence was found higher for Tapri 47.05% and 47.05% at district Hyderabad while, Pateri shows higher prevalence of 37.93% and 34.48% at Tando Allahyar district on both diagnostic techniques. Major gross pathological lesions were observed on the mucosal surface with moderate haemorrhages and purulent exudates accumulated in lumen of the trachea. Multifocal and diffuse type lesions and accumulation of serous fluid in pleural cavity were prominent in lungs. Epithelial linings of bronchi and alveoli were disrupted, thickened interlobular septa with extensive infiltration of polymorphic nucleated cells. Histopathological lesions were prominent in trachea as compared to lungs.