A study was conducted to evaluate the effects of different dietary lysine regimens on the subsequent productive performance, egg persistency and economics of Lakha, Mianwali, Mushki and Peshawari varieties of indigenous Aseel chicken from 28-43 weeks of age. For this purpose, 96 pullets constituting 24 from each variety, were randomly selected and maintained under standard management conditions. These birds were reared under 3 different dietary lysine regimens containing lysine 1.3 % (L1) for six weeks, 1.4 and 1.2 % (L2) each for three weeks and 1.5, 1.3 and1.1% (L3) each for two weeks. These dietary lysine regimens were fed from 0-6th week. The feed intake was significantly (P≤0.05) higher in Mianwali variety than Lakha, Peshawari and Mushki varieties. The cumulative egg number per hen, cumulative egg mass (g), egg weight (g), Hen day production (%) and Hen house production (%) were significantly (P≤0.05) higher in birds reared under L3 than L2 and L1 lysine regimens. Mushki variety showed highest egg production and persistency (28th to 35th week) than Peshawari, Mianwali and Lakha varieties and the birds reared under L3 were found to be more economical than L2 and L1 lysine regimens.