Article Abstract

Volume 22, No. (2), 2012 (June)
HEPATOPROTECTIVE ROLE OF EXTRACTS OF MOMORDICA CHARANTIA L. IN ACETAMINOPHEN-INDUCED TOXICITY IN RABBITS
K. Zahra, M. A. Malik, M. S. Mughal , M. Arshad, M. I. Sohail

K. Zahra, M. A. Malik, M. S. Mughal, M. Arshad, M. I. Sohail

1 Department of Zoology, GC University, Lahore, Pakistan,
2 Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan
3 Department of Biological Sciences, University of Sargodha, Sargodha, Pakistan

Corresponding Author: imransohail@gcu.edu.pk
DOI: NA
Page Number(s): 273-277
Published Online First: April 01, 2012
Publication Date: April 01, 2012
ABSTRACT

An analysis of different serum enzymes including ALT, AST, ALP and LDH was carried out to evaluate the hepatoprotective and hepatocurative effects of Momordica charantia. The study was divided in two phases. In first the phase, liver toxicity was induced in rabbits with administration of acetaminophen, and then Momordica extract was given and hepatocurative effects were observed. The results indicated significant decrease in the elevated concentrations of these enzymes in acetaminophen-intoxicated rabbits. In the second phase, the extract of Momordica was given to the rabbits orally for 10 and 15 days respectively. Then, the animals were administered with acetaminophen and hepatoprotective effects of Momordica were observed. The hepatoprotective effects of Momordica extract was found to be more effective after 15 days as there was less elevation of the serum enzymes after liver damage.

Keywords: Serum Enzymes, Hepatoprotective, Hepatocurative, Momordica charantia, Acetaminophen
Indicators
Metrics

Cite Score: 1.3

JCR Year: 2025

Indexing
Status

Web of Science (SCIE)

SCOPUS (Q3)

Journal Metrics
Current

Journal Impact Factor: 0.5

HEC Category: W

ISSN Details
Verified

Print ISSN: 1018-7081

Electronic ISSN: 2309-8694

Search the Journal

Use the fields below to search for articles by Title, Author, or Keywords.