J. Xu, A. Zhou, Z. Wang and D. Ai
Chengdu Vocational College of Agricultural Science and Technology, Chengdu 611130, P.R. China *Key Laboratory for Animal Disease –Resistance Nutrition of China Ministry of Education, Ya’an, Sichuan 625014, China
Antigen protein contained in soybeans are the major cause of allergic reaction in young animals. In this study, glycinin and β-conglycinin were purified material and experimentally tested at concentration of 0.1, 5, and 10 mg/ml for their effects on integrity and immune responses of mouse intestinal epithelial cells. At 5 mg/ml or above, glycinin and β-conglycinin undermined the integrity of intestinal epithelial cells, inhibited epithelial cell proliferation, and significantly increase the levels of LDH and GOT released to the culture medium. The administration of glycinin and β-conglycinin also significantly promoted the secretion of inflammatory cytokines (IL-2, IL-6, IL-8), a key feature in allergic reactions.
Cite Score: 1.3
JCR Year: 2025
Web of Science (SCIE)
SCOPUS (Q3)
Journal Impact Factor: 0.5
HEC Category: W
Print ISSN: 1018-7081
Electronic ISSN: 2309-8694
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