A total of 290 horses were examined to determine the prevalence of Anhidrosis, find suitable therapy and to record effect of the condition on serum glucose level. The affected horses were divided in two groups i.e. group A received sodium chloride orally 80 grams for 3 days along with injection lasix 100 mg (10ml) for 3 days and ample drinking water. Group B received thyroxin 50 mg orally daily for 3 days , vitamin E 2000 IU orally, normal saline and ample drinking water. The prevalence of Anhidrosis was found to be 12.41 percent (36/290). Serum glucose levels were on higher side in affected horses which returned to normal after recovery, however, blood cholesterol level remained same before and after treatment. In group A and B 33(5/15) and 73.33(11/15) percent horse showed recovery, respectively.